閉経後のホルモン療法は,異常なグルコース耐性を持つ女性の動脈硬化症の進行と関連しています
Barbara V Howard1, Judith Hsia, Pamela Ouyang
1MedStar Research Institute, 6495 New Hampshire Ave, Suite 201, Hyattsville, MD 20783, USA. Barbara.V.Howard@MedStar.net
Circulation
|July 1, 2004
まとめ
閉経後のホルモン療法は,異常なグルコース耐性を持つ女性の冠動脈動脈硬化症を悪化させる. PHTは,心血管疾患のリスクと炎症マーカーの増加のために,糖尿病の女性には推奨されません.
科学分野:
- 心血管疾患は,心血管疾患である.
- エンドクリノロジー エンドクリノロジー
- 女性の健康 女性の健康
背景:
- 異常なグルコース耐性 (AGT) は,特に閉経後の女性において,心血管疾患 (CVD) のリスクを高めます.
- 閉経後のホルモン療法 (PHT) は,心血管疾患のリスクの増加と関連しており,糖尿病と非糖尿病の女性に同様の効果が観察されています.
研究 の 目的:
- AGTを患っている閉経後の女性の心血管疾患にPHTがより悪い影響を与えるという仮説を検証する.
主な方法:
- 423人の閉経後の女性,アテロスクレロシス,またはAGTなしで,PHTまたはプラセボに約2.8年間ランダムに割り当てられました.
- 冠動脈動脈硬化症の進行は,連続血管図を用いて評価された.
- 脂質プロファイル,炎症マーカー (C反応性タンパク質,フィブリノゲン),グルコース,インスリン,およびインスリン抵抗性 (HOMA) を測定しました.
主要な成果:
- PHTは,AGTの女性において,C反応性タンパク質とフィブリノゲンの有害な変化を誘導した.
- 動脈硬化症の進行は,AGTの女性ではより大きく,PHTによって強化されました.
- PHTは,AGTの女性の断食グルコース,インスリン,およびインスリン抵抗性のわずかな改善を示しました.
結論:
- PHTは,冠動脈動脈硬化症と炎症マーカーを悪化させる.
- これらの副作用のために,PHTは糖尿病の女性には推奨されません.
- AGTの女性におけるインスリン抵抗性および血糖値に対するPHTの潜在的な利点を探るには,さらなる研究が必要です.
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