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遠隔空間記憶にとって重要な新皮質の再編成部位
Thibault Maviel1, Thomas P Durkin, Frédérique Menzaghi
1Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Université de Bordeaux 1, Avenue des Facultés, 33405 Talence, France.
Science (New York, N.Y.)
|July 3, 2004
まとめ
遠隔空間記憶は海馬に保存されていません. 代わりに,前頭前皮質と帯状皮質は,マウスの長期的な空間記憶の保存と検索に不可欠です.
科学分野:
- 神経科学は神経科学である.
- 認知神経科学とは
- 記憶の研究 記憶の研究
背景:
- 海馬は空間的な記憶を形成するのに不可欠です.
- 長期記憶は,ヒポカンプスにだけ保存されているわけではありません.
- リモートメモリストレージのニューラル基盤を理解することは極めて重要です.
研究 の 目的:
- 遠隔空間記憶の保存と回収に関与する脳の領域を特定する.
- 記憶の統合中の脳領域間のダイナミックな相互作用を調査する.
- 長期記憶記憶と関連した構造的,機能的変化を明らかにする.
主な方法:
- マウスにおける機能的脳イメージング.
- ネズミにおける地域特有のニューロン不活性化.
- 活動に依存する遺伝子のイメージング.
主要な成果:
- 前頭前帯状皮質と前帯状皮質は,遠隔空間記憶の保存と回収に不可欠です.
- パリエタルおよびレトロスプレニアル皮質は,遠隔記憶の統合に関与しています.
- シナプトゲネシスとラミナルの再編成を含む構造の変化は,長期記憶の貯蔵中に新皮質領域で起こります.
- ヒッポカンプスと後帯状皮質の機能的解離が観察される.
結論:
- 空間記憶の統合には,海馬と皮質の間の時間依存の対話が伴う.
- 広範囲に広がる皮質ネットワークは,海馬から独立して保存された遠隔記憶のリコールと使用を仲介します.
- 長期記憶の貯蔵には,皮質の領域における重要な神経可塑性変化が含まれます.
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