レセプタータンパク質チロシンフォスファタゼによるネットリン媒介アクソン吸引の抑制

Chieh Chang1, Timothy W Yu, Cornelia I Bargmann

  • 1Department of Biological Sciences, Howard Hughes Medical Institute (HHMI), Stanford University, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|July 3, 2004
PubMed
まとめ

clr-1における機能喪失変異は,ネトリンの引き寄せを強化し,軸索誘導欠陥を抑制する. レセプタータンパク質チロシンフォスファタゼであるCLR-1は,Caenorhabditis elegansのUNC-40/DCC受容体を通じたシグナル伝達を阻害する.

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