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Updated: Jul 5, 2026

Live Cell Imaging of the TGF- β/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System
11:06

Live Cell Imaging of the TGF- β/Smad3 Signaling Pathway In Vitro and In Vivo Using an Adenovirus Reporter System

Published on: July 30, 2018

サイクリン依存キナーゼは,Smadsの反増殖機能を調節する

Isao Matsuura1, Natalia G Denissova, Guannan Wang

  • 1Center for Advanced Biotechnology and Medicine,Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.

Nature
|July 9, 2004
PubMed
まとめ

サイクリン依存キナーゼ (CDK) はSmad3をリン酸化し,成長抑制作用を抑制する. このCDK媒介によるSmad3の抑制は,がんの発生と,成長因子-β (TGF-β) の変容に対する抵抗を誘発する可能性がある.

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Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay

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