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Updated: Mar 23, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
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A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

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サイクロフィリンAのTRIM5への逆転移は,フクロウ猿のHIV-1に対する抵抗性を説明する

David M Sayah1, Elena Sokolskaja, Lionel Berthoux

  • 1Department of Microbiology, Columbia University, College of Physicians and Surgeons, 701 West 168th Street, HHSC 1502 New York, New York 10032, USA.

Nature
|July 10, 2004
PubMed
まとめ

オオカミ類は,融合タンパク質であるTRIMCypを介してヒト免疫不全ウイルス1型 (HIV-1) を抑制する. この抗ウイルスTRIMCyp遺伝子は,LINE-1レトロトランポゾンから発生し,TRIM5遺伝子にサイクロフィリンA (CypA) DNAを挿入した.

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