妊娠中の胎児メゼンキマ幹細胞の密輸から数十年後の女性の骨髄と骨の微化学反応

Keelin O'Donoghue¹, Jerry Chan, Josu de la Fuente

¹Institute of Reproductive and Developmental Biology, Division of Paediatrics, Obstetrics and Gynaecology, Imperial College London, Hammersmith Campus, London W12 0NN, UK. k.odonoghue@imperial.ac.uk

Lancet (London, England)

|July 13, 2004

まとめ

胎児の幹細胞は,妊娠中に母親に移転し,骨髄で生涯持続することができます. XY光 in-situハイブリデーションで特定されたこのマイクロキメリズムは,男性妊娠の女性では一般的です.

科学分野:

生殖生物学生殖生物学
免疫学免疫学とは
幹細胞生物学幹細胞生物学とは

背景:

胎児の細胞は,妊娠中に母の循環に入り込むことが知られている.
持続的な胎児マイクロキメリスムは,自己免疫疾患を有する女性において観察される.
健康な女性の胎児マイクロキメリスムの発生率と細胞タイプは,ほとんど不明のままです.

研究の目的:

健康な女性の胎児マイクロキメリスムの頻度と細胞タイプを調査する.
胎児のメゼンキマ幹細胞が母親の臓器,特に骨髄と肋骨に持続するという仮説を検証する.

主な方法:

女性の骨髄と肋骨の分析.
XY光インシトゥハイブリダイゼーション (FISH) を使用した雄性細胞の識別.
男性妊娠した女性と対照群の比較.

主要な成果:

男性の妊娠したすべての女性の骨髄由来メゼンキマ幹細胞と肋骨部分に男性細胞が検出されました (9/9).
制御群の女性では男性細胞が見つかりませんでした (0/5).
統計的有意性は確立されました (p=0.0005).

結論:

妊娠中に移植された胎児の幹細胞は,母親の骨髄に埋め込まれることができます.
これらの胎児細胞は,母親の生涯にわたって存在します.
発見は,正常な妊娠,産科合併症,移植の結果を理解するための意味を持つ.

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