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Updated: Jul 16, 2026

Isotopic Effect in Double Proton Transfer Process of Porphycene Investigated by Enhanced QM/MM Method
05:51

Isotopic Effect in Double Proton Transfer Process of Porphycene Investigated by Enhanced QM/MM Method

Published on: July 19, 2019

COMT触媒によるメチル転移の運動同位体効果のQM/MMの決定は,圧縮仮説を支持していない

Giuseppe D Ruggiero1, Ian H Williams, Maite Roca

  • 1Department of Chemistry, University of Bath, BA2 7AY Bath, UK.

Journal of the American Chemical Society
|July 15, 2004
PubMed
まとめ

この研究では,S-アデノシルメチオニンメチル化のための運動同位体効果を計算しました. 酵素カテキルO-メチルトランスフェラーゼは,移行状態における力の定数の増加により,大きな逆効果を示します.

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