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Updated: Jul 20, 2026

Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts
10:04

Establishment of Proliferative Tetraploid Cells from Nontransformed Human Fibroblasts

Published on: January 8, 2017

野生型p53は細胞サイクル制御を回復し,変異p53アレルを持つ細胞における遺伝子増幅を抑制する

Y Yin1, M A Tainsky, F Z Bischoff

  • 1Salk Institute San Diego, California 92186-5800.

Cell
|September 18, 1992
PubMed
まとめ

腫瘍抑制タンパク質p53は,遺伝子増幅を防止し,細胞サイクル制御を維持するために重要です. Li-Fraumeni症候群の細胞におけるp53機能の喪失は,腫瘍の進行中に制御不能な細胞分裂と遺伝的不安定につながります.

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Yeast As a Chassis for Developing Functional Assays to Study Human P5314:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence04:56

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

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