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Updated: Jul 13, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
11:36

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones

Published on: July 25, 2019

A20のデウビキチン化およびウビキチンリガゼドメインは,NF-kappaBシグナル伝達をダウンレギュレーションする

Ingrid E Wertz1, Karen M O'Rourke, Honglin Zhou

  • 1Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA.

Nature
|July 20, 2004
PubMed
まとめ

A20タンパク質は,重要なシグナル伝達分子であるRIPにユビキチン鎖を取り除き追加することで,慢性炎症を抑制する. この二重アクションは,RIPを分解,NF-kappaBのシグナル伝達をダウンレギュレーションし,細胞死を防止することをターゲットとしています.

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