ニューロトロフィン信号で距離を走るか走らないか
Louis F Reichardt1, William C Mobley
1Program in Neuroscience, Department of Physiology and Howard Hughes Medical Institute, University of California, San Francisco, 1550 Fourth Street, Room 284A, San Francisco, CA 94143, USA.
Cell
|July 21, 2004
まとめ
神経成長因子 (NGF) とニューロトロフィン-3 (NT-3) はTrkA受容体を通して信号を送るが,NGFだけがニューロンの生存を促進する. この違いは,NT-3とは異なり,NGFがTrkA受容体の内部化と逆行輸送を誘発する能力から生じる.
科学分野:
- 神経科学は神経科学である.
- 細胞生物学 細胞生物学
- 発達生物学 発達生物学について
背景:
- 神経成長因子 (NGF) とニューロトロフィン-3 (NT-3) は,TrkA受容体と結合する重要なニューロトロフィンです.
- NGFとNT-3の両方が,交感性ニューロンの発達と機能に関与しています.
- 同じ受容体に結合しているにもかかわらず,NGFは神経細胞の生存と分化をサポートし,NT-3はこれらの同じ結果を生じさせない.
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