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Updated: Jul 14, 2026

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Toca-1は,N-WASP-WIP複合体を活性化することによって,Cdc42-依存のアクチン核化を媒介する

Hsin-Yi Henry Ho1, Rajat Rohatgi, Andres M Lebensohn

  • 1Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|July 21, 2004
PubMed
まとめ

研究者らは,Cdc42に依存したアクチン組成に不可欠なタンパク質であるToca-1を特定しました. Toca-1は,N-WASPと共に,Cdc42シグナル伝達に不可欠であり,アクチンポリメリゼーションとウィスコット・オルドリッヒ症候群の理解を修正しています.

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