動的同位体効果は,P450触媒によるN-デアルキル化における唯一の酸化物質として鉄オクセンを含んでいる

Tamara S Dowers1, Dan A Rock, Denise A Rock

  • 1Department of Chemistry, P.O. Box 644630, Washington State University, Pullman, Washington 99164-4630, USA.

まとめ

サイトクロームP450酵素は,N-dealkylationを触媒化する. N-オキシドを酸素ドナーとして使用した研究者は,酸化が鉄-オクセン種を通じて発生し,完全な酵素系を模倣することを発見しました.

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