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関連する概念動画

Cross-bridge Cycle01:26

Cross-bridge Cycle

As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
Centroid of a Body01:16

Centroid of a Body

The centroid is an important concept in engineering, physics, and mechanics. It is the geometric center of a body. It always lies within the body except in cases with holes or cavities. When the material that a body is composed of is uniform or homogeneous, the centroid coincides with its center of mass or the center of gravity.
For a homogeneous body with constant density, the centroid can usually be found using equations representing a balance of the moments of the body's volume. If the...
Centroid of a Body: Problem Solving01:03

Centroid of a Body: Problem Solving

The centroid of a body is a crucial concept in engineering and physics. Finding the centroid of a body can help determine its stability, its balance point, and even its design. In this context, consider a thin wire bent in the form of a quarter circular arc. Polar coordinates are used to calculate the centroid. The wire is first divided into small differential elements of a length equal to the radius multiplied by the differential angle.
The x-coordinates and y-coordinates of each element's...
Excitation-Contraction Coupling in Skeletal Muscles01:20

Excitation-Contraction Coupling in Skeletal Muscles

Excitation-contraction coupling is a series of events that occur between generating an action potential and initiating a muscle contraction. It occurs at the triad, a structure found in skeletal muscle fibers that comprise a T-tubule and terminal cisternae of the sarcoplasmic reticulum on each side. These triads are visible in longitudinally sectioned muscle fibers. They are typically located at the A-I junction — the junction between the A and I bands of the sarcomere.
When an action potential...
Muscle Coordination and Action01:24

Muscle Coordination and Action

Muscle coordination is a complex and finely tuned process essential for smooth and purposeful movements like flexion, extension, adduction, abduction, and rotation. The human body orchestrates the actions of various muscles working in concert, each with a specific role. Four functional types describe how muscles work together: agonist, antagonist, synergist, and fixator.
Agonists
Agonist muscles, often called prime movers, are the primary muscles responsible for producing a specific movement.
Relative Motion Analysis - Velocity01:24

Relative Motion Analysis - Velocity

A stroke engine has a slider-crank mechanism that converts rotational motion from the crank into linear motion of the slider or vice versa. This mechanism consists of three main parts: the crank, the connecting rod, and the slider.
When an external force is exerted, it sets the crank into a rotational movement. This, in turn, instigates the motion of the connecting rod, leading to what is referred to as a general plane motion. This process involves two key points - point A on the connecting rod...

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関連する実験動画

Updated: Jul 6, 2026

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running
08:26

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

Published on: July 17, 2020

リガンド結合中のトレース運動中介物質.

Tanja Mittag1, Brian Schaffhausen, Ulrich L Günther

  • 1J. W. Goethe University, Frankfurt, Center for Biomolecular Magnetic Resonance, Institute of Biophysical Chemistry, Biocenter N230, Marie-Curie-Str. 9, 60439 Frankfurt, Germany.

Journal of the American Chemical Society
|July 22, 2004
PubMed
まとめ

核磁共振 (NMR) は,原子レベルのタンパク質-リガンド結合ダイナミクスを明らかにします. NMR線形を分析すると,特定の運動中間物質が特定され,結合特異性が説明されます.

科学分野:

  • バイオケミストリー バイオケミストリー
  • 構造生物学 構造生物学とは
  • 化学物理 化学物理

背景:

  • タンパク質-リガンドの相互作用は,生物学的プロセスにとって極めて重要です.
  • 静的構造の決定は,ダイナミックな結合イベントへの限られた洞察を提供します.
  • 生物物理学的方法はグローバルなダイナミクスを提供しますが,核磁気共鳴 (NMR) はサイト固有の原子解像度を提供します.

研究 の 目的:

  • タンパク質-リガンド結合運動を分析するための新しいNMRベースの方法を開発し,適用する.
  • アミノ酸レベルでの結合過程中の一時的な運動中間物質を特定し,特徴づけること.
  • リガンド誘発の中間状態が結合特異性にどのように影響するか解明する.

主な方法:

  • 核磁共鳴 (NMR) 線形の分析. 核磁共鳴 (NMR) 線形の分析. 核磁共鳴 (NMR) 線形の分析. 核磁共鳴 (NMR) 線形の分析. 核磁共鳴 (NMR) 線形の分析. 核磁共鳴 (NMR) 線形の分析. 核磁共鳴 (NMR) 線形の分析. 核磁共鳴 (NMR) 線形の分析. 核磁共鳴 (NMR) 線形の分析.
  • 原子解像度でのサイト固有のダイナミクスの特徴化.
  • タンパク質-リガンド反応経路における長寿命の運動中間物質の識別.

主要な成果:

さらに関連する動画

Comparison of Kinetic Characteristics of Footwork during Stroke in Table Tennis: Cross-Step and Chasse Step
07:19

Comparison of Kinetic Characteristics of Footwork during Stroke in Table Tennis: Cross-Step and Chasse Step

Published on: June 16, 2021

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

関連する実験動画

Last Updated: Jul 6, 2026

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running
08:26

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

Published on: July 17, 2020

Comparison of Kinetic Characteristics of Footwork during Stroke in Table Tennis: Cross-Step and Chasse Step
07:19

Comparison of Kinetic Characteristics of Footwork during Stroke in Table Tennis: Cross-Step and Chasse Step

Published on: June 16, 2021

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

  • NMR線形分析により,個々のアミノ酸レベルの運動中間物質を特定することが示された.
  • 異なるリガンドがタンパク質-リガンドの相互作用中に異なる中間状態を誘導することを示した.
  • これらの中間状態の寿命とタンパク質-リガンド結合の特異性との間の相関を確立した.

    • 結論:

    • NMR線形分析は,タンパク質-リガンド相互作用の運動機構を視覚化するための強力なツールを提供します.
    • リガンド誘発性運動中間物質は,結合特異性を決定する上で重要な役割を果たします.
    • このアプローチは,分子認識を制御するダイナミックなイベントに関する直接的,サイト固有の洞察を提供します.