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進化遺伝学: Y. pestis 感染症における CCR5 の曖昧な役割
Stephen J Elvin1, E Diane Williamson, Joanne C Scott
1Defence Science and Technology Laboratories, Porton Down, Salisbury SP4 0JQ, UK.
Nature
|July 27, 2004
まとめ
ケモカイン受容体CCR5欠乏症は,鼠をペストから保護しません. しかし,Ccr5欠乏したマクロファージは,Yersinia pestis細菌の吸収を in vitroで減少させ,ペスト感染症におけるCCR5の複雑な役割を示唆した.
科学分野:
- 免疫学 免疫学とは
- 微生物学 微生物学とは
- 遺伝学 遺伝学とは
背景:
- CCR5受容体は,免疫反応において重要な役割を果たします.
- 白人の一般的なCCR5遺伝子変異 (CCR5Delta32) がペストに対する保護を提供すると仮定された.
- 以前の研究では,CCR5欠乏症がYersinia pestis感染を予防しない可能性があることが示唆されていました.
研究 の 目的:
- Yersinia pestis感染におけるケモカイン受容体CCR5の役割を調査する.
- CCR5Delta32変異がペストに対する保護を与えるという仮説を検証する.
- Ccr5欠乏がマクロファージによるYersinia pestisの吸収に与える影響を分析する.
主な方法:
- Ccr5欠乏性および野生型のマウスのYersinia pestis.感染
- Ccr5欠乏症および野生型マウスのマクロファージを用いたインビトロファゴサイトーシスアッセイ.
- 感染したマウスの生存分析.
主要な成果:
- Ccr5欠乏したマウスとYersinia pestisに感染した野生型のマウスの生存率に有意な差はありません.
- Ccr5欠乏したマクロファージによるYersinia pestisの吸収を in vitroで大幅に減少させた.
- 疫病に対するCCR5Delta32変異の保護的役割は不明である.
結論:
- CCR5欠乏症は,マウスモデルでペストに対する保護を与えるようには見えません.
- Ccr5はマクロファージによるYersinia pestisの吸収に役割を果たし,以前理解されていたよりもより複雑な感染への関与を示しています.
- CCR5がペストに対する宿主防御における正確な役割を明らかにするために,さらなる研究が必要である.
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