食事中のコレステロールによって引き起こされる血清アミロイドAの上昇は,マウスの動脈硬化症の増加と関連しています
Katherine E Lewis1, Elizabeth A Kirk, Thomas O McDonald
1Department of Medicine, University of Washington, Seattle, Wash 98195-6426, USA.
Circulation
|July 28, 2004
まとめ
高脂肪食は,血清アミロイドA (SAA) を増加させ,マウスの動脈硬化を引き起こします. この研究では,SAAはコレステロールとは無関係に動脈硬化を促進し,血管内のリポプロテイン保持を高めることを示唆しています.
科学分野:
- 心血管研究に関する研究.
- 脂質代謝 脂質代謝とは
- 動脈硬化症の病原病原化について
背景:
- 血清アミロイドA (SAA) の上昇は,心血管疾患のリスクと関連しています.
- ダイエット脂肪とコレステロールはSAAレベルを上昇させる可能性があります.
- SAAは,リポプロテイン-プロテオグリカン結合を促進することによって,アテロゲネシスを促進する可能性があります.
研究 の 目的:
- 食事によるSAA増加が,血コレステロールとは無関係に動脈硬化を促進するかどうかを調査する.
- 動脈硬化症の発達におけるSAAの直接的な役割を調査する.
主な方法:
- LDL受容体ゼロの雌マウスは,10週間,コレステロールを含むまたは含まれない高脂肪食を摂取した.
- 血SAAとコレステロールレベルを測定した.
- 動脈硬化症の程度と病変におけるSAAの存在を分析した.
主要な成果:
- 高脂肪食は,血のSAAレベルを上昇させた.
- 食事中のコレステロールは,血コレステロールを増加させずにSAAをさらに上昇させた.
- SAA濃度の上昇は,より大きな動脈硬化症と相関しています.
- SAAは動脈硬化性病変で発見され,直接的な役割を示唆しました.
結論:
- 食事中のコレステロールは,プラズマ脂質タンパク質とは無関係にSAAと動脈硬化を増加させる.
- SAAは,SAAに富んだHDLを血管タンパク質グリカンに保持することを媒介することによって,動脈硬化を直接促進する可能性があります.
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