APC変異は,大腸直腸腫瘍発生の初期に発生する
S M Powell1, N Zilz, Y Beazer-Barclay
1Johns Hopkins Oncology Center, Baltimore, Maryland 21231-1001.
Nature
|September 17, 1992
まとめ
Adenomatous Polyposis Coli (APC) 遺伝子の変異は,ヒトの結腸直腸腫瘍の発症に不可欠である. これらのAPC遺伝子変異は,初期段階のアデノマに存在し,腫瘍の進行中に持続します.
科学分野:
- 腫瘍学 腫瘍学
- 分子生物学は分子生物学である.
- 遺伝学 遺伝学とは
背景:
- 人間の腫瘍発生には,腫瘍遺伝子の変異と腫瘍抑制遺伝子の変異が含まれます.
- 一般的な成人がんの初期段階における重要な突然変異は,大抵未定義のままである.
研究 の 目的:
- ヒトの結腸直腸腫瘍の早期発現におけるアデノマトース・ポリポシス・コリ (APC) 遺伝子変異の役割を調査する.
- APC遺伝子変異が腫瘍発生における重要な初期イベントであるかどうかを決定する.
主な方法:
- 41人のヒトの結腸直腸腫瘍 (アデノマと癌) のシーケンス分析.
- 異なる腫瘍のステージとサイズにおけるAPC遺伝子変異の存在の評価.
主要な成果:
- 大腸直腸がん (60%) とアデノーマ (63%) のほとんどは,変異したAPC遺伝子を宿していた.
- APC遺伝子変異は,小さな腺腫 (0.5cm) を含む,最も早期に検出可能な腫瘍で特定されました.
- APC遺伝子の変異頻度は,腫瘍が良性から悪性へと進行する過程で一貫していた.
結論:
- APC遺伝子の変異は,大腸直腸腫瘍の発症において重要な役割を果たします.
- APC遺伝子変異は,ヒトの結腸直腸がんの発症の初期および重要なイベントです.
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