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Updated: Jul 8, 2026

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
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Published on: April 6, 2016

肺がんにおけるゲフィチニブ感受性EGFR変異は,抗アポプトシス経路を活性化する

Raffaella Sordella1, Daphne W Bell, Daniel A Haber

  • 1Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.

Science (New York, N.Y.)
|July 31, 2004
PubMed
まとめ

ゲフィチニブは,非小細胞肺がん (NSCLC) で変異した表皮成長因子受容体 (EGFR) を標的とする. この薬は生存経路を阻害し,がん細胞死につながり,その有効性を説明する可能性がある.

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