人間の皮膚の共生体であるPropionibacterium acnesの完全なゲノム配列

Holger Brüggemann¹, Anke Henne, Frank Hoster

¹Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Göttingen, Grisebachstrasse 8, 37077 Göttingen, Germany. hbruegg@pasteur.fr

Science (New York, N.Y.)

|August 3, 2004

まとめ

一般的な皮膚細菌であるPropionibacterium acnesは,宿主分子を分解できる遺伝子を保有しています. これらの要因は,の炎症および関連する疾患に寄与する可能性があります.

科学分野:

微生物学微生物学とは
皮膚科皮膚科について
ゲノミクスゲノミクスとは

背景:

プロピオニバクテリウム・アクネス (P. acnes) は,成人ヒトの皮膚に多く見られる共生性細菌である.
脂質の卵泡に宿っており, (acne vulgaris) と関連している.
皮膚の健康と病気における細菌の役割は調査中です.

研究の目的:

P. acnes. のゲノム配列を分析するために.
宿主分子の分解に関与する遺伝子とその産物を識別する.
P. acnesに関連する疾患に寄与する潜在的な毒性の要因を探求する.

主な方法:

P. acnes. の全ゲノムシーケンシング
推定遺伝子とタンパク質機能のバイオ情報分析.
酵素と表面因子の識別.

主要な成果:

P. acnes のゲノムには2333の推定遺伝子が含まれています.
多くの遺伝子は,シアリダゼ,ニューラミニダゼ,エンドグリコセラミダゼ,リパゼなどの宿主分子を分解する酵素をコードする.
毛穴形成因子と表面に関連した免疫原性因子を特定しました.

結論:

P. acnesは,宿主の皮膚成分と相互作用し,それを劣化させるための遺伝的レパートリーを持っています.
特定された要因は,の炎症および他のP. acnesに関連する皮膚疾患の炎症の発症に役割を果たす可能性があります.

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