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Updated: Jun 25, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

p53-hDM2相互作用の螺旋ベータペプチド阻害剤である

Joshua A Kritzer1, James D Lear, Michael E Hodsdon

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

Journal of the American Chemical Society
|August 5, 2004
PubMed
まとめ

研究者は,p53トランス活性化ドメイン (p53AD) 構造を模倣する新しいβ3ペプチドを設計しました. これらのペプチドは,高い親和性でhDM2に結合し,p53.hDM2の相互作用を妨害することによって,がん治療のための新しい戦略を提供します.

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