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Updated: Jul 11, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

P-キロゲン系フォスフォラン合成のためのステレオセレクティブサイクリングとピラミッド逆転戦略

Garrett Hoge1

  • 1Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA. garrett.hoge@pfizer.com

Journal of the American Chemical Society
|August 12, 2004
PubMed
まとめ

研究者らは,非対称な触媒に不可欠なキラルフォスフォランを合成するための新しい方法を開発しました. これらの化合物,特に"トランス/トランス"イソマーは,プレガバリンのような医薬品の生産における重要なステップである高度なエナチオセレクティブ水素化を可能にします.

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Thermal and Photochemical Electrocyclic Reactions: Overview

Electrocyclic reactions are reversible reactions. They involve an intramolecular cyclization or ring-opening of a conjugated polyene. Shown below are two examples of electrocyclic reactions. In the first reaction, the formation of the cyclic product is favored. In contrast, in the second reaction, ring-opening is favored due to the high ring strain associated with cyclobutene formation.
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Woodward–Hoffmann Selection Rules and Microscopic Reversibility

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Pericyclic Reactions: Introduction

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