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Vaccinia Virus Infection & Temporal Analysis of Virus Gene Expression: Part 2
Published on: April 10, 2009
ワクチンを接種した症例における水の伝染性:家庭での接触調査
Jane F Seward1, John X Zhang, Teresa J Maupin
1Centers for Disease Control and Prevention, Atlanta, Ga 30333, USA. jseward@cdc.gov
JAMA
|August 12, 2004
まとめ
水ワクチンは非常に有効で,すべての水の症例の約80%と,ほぼすべての中等から重度の感染症を予防します. 突破性感染症のワクチン接種を受けた個人は,ワクチン接種を受けていない個人に比べて,特に病変が少ない個人に比べて,伝染性が低い.
科学分野:
- エピデミオロジー エピデミオロジー
- ワクチン学 ワクチン学
背景:
- ワクチン接種した個体における水 (水) の伝染性に関するデータは限られている.
- ワクチンを接種した集団における伝播ダイナミクスを理解することは,公衆衛生戦略にとって極めて重要です.
研究 の 目的:
- 病歴とワクチン接種状況に基づいて,世帯内の二次性発作率を決定する.
- Varicellaワクチンの有効性を推定するために.
主な方法:
- ロサンゼルス郡 (1997年-2001年) の人口ベースの監視プロジェクトでは,水の症例を追跡しました.
- 収集されたデータには,人口統計,臨床詳細,症例のワクチン接種状況,および家庭の連絡先が含まれています.
- 2次発作の発生率とワクチンの有効性は,未ワクチンおよびワクチン接種した個人のデータを用いて計算されました.
主要な成果:
- ワクチンを接種した症例は,ワクチンを受けていない症例の半分ほど感染力がありました.
- の予防にワクチンの有効性は78.9%でした.
- 薬の有効性は,中程度の病気では92%に達し,重症では100%に達しました.
結論:
- Varicellaワクチンは,家庭での濃度の暴露下でも,中程度から重度の病気を予防する上で高い有効性を示しています.
- ワクチンを接種した個体におけるブレイク・スルー・ヴァリチェッラ感染症は,ワクチン接種されていない個体よりも感染性が低い.
- 突破症例の伝染性は,皮膚病変の数と相関しています.
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