Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Antibiotic Selection00:57

Antibiotic Selection

Overview
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...
Bacterial Phylum Tenericutes01:24

Bacterial Phylum Tenericutes

The phylum Tenericutes, which includes the single class Mollicutes, comprises bacteria that lack cell walls. The term "Mollicutes" derives from the Latin word mollis, meaning "soft." These organisms are among the smallest known and are commonly referred to as mycoplasmas due to the prominence of the genus Mycoplasma, which includes well-known human pathogens. Despite their inability to stain gram-positively (a result of their lack of cell walls), mycoplasmas are phylogenetically related to the...
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
Colonisation of Pathogens01:25

Colonisation of Pathogens

Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Auxin response and PIN-mediated transport in chlorophyte algae.

Journal of integrative plant biology·2026
Same author

Toward systems agroecology: Risk-reward balance, emergent plant communities, and temporal weather map in multiplant farming.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Simulation-based inference of cell migration dynamics in complex spatial environments.

NPJ systems biology and applications·2026
Same author

Differentiation between regulated and disrupted growth arrests allows tailoring of effective treatments for antibiotic persistence.

Science advances·2026
Same author

Harnessing droplet microfluidics and morphology-based deep learning for the label-free study of polymicrobial-phage interactions.

Communications biology·2025
Same author

Myosin II regulates cellular thermo-adaptability and the efficiency of immune responses.

Developmental cell·2025
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
関連記事をすべて見る

関連する実験動画

Updated: Jun 10, 2026

Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains
06:45

Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains

Published on: January 18, 2014

細菌の持続性は,フェノタイプのスイッチとして機能します.

Nathalie Q Balaban1, Jack Merrin, Remy Chait

  • 1Laboratory of Living Matter and Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. nathalieqb@phys.huji.ac.il

Science (New York, N.Y.)
|August 17, 2004
PubMed
まとめ
この要約は機械生成です。

バクテリア集団は,抗生物質に耐えて,遺伝的変異を伴わずに生存する持続性のある細胞を発現します. これらの持続細胞は,表型変異によって発生し,成長速度が遅いため,細菌感染と適応を理解する上で極めて重要です.

さらに関連する動画

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes
07:44

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes

Published on: February 14, 2025

関連する実験動画

Last Updated: Jun 10, 2026

Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains
06:45

Monitoring Intraspecies Competition in a Bacterial Cell Population by Cocultivation of Fluorescently Labelled Strains

Published on: January 18, 2014

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes
07:44

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes

Published on: February 14, 2025

科学分野:

  • 微生物学と微生物生理学
  • バクテリアのストレス反応と適応

背景:

  • 微生物集団のわずかな部分は,遺伝的耐性なしに抗生物質治療を生き延びることができます.
  • 持続性細胞として知られるこれらの生き残った細胞は,子孫に抵抗性の特徴を継承しません.
  • 細菌の持続性の背後にあるメカニズムを理解することは,感染症と闘うために不可欠です.

研究 の 目的:

  • 単細胞レベルでバクテリアの持続現象を調査する.
  • 微生物集団における既存の異質性の持続性に関する役割を調査する.
  • 持続細胞形成への切り替えを説明する定量モデルを開発する.

主な方法:

  • 単一の細菌細胞の高解像度観察のためのマイクロ流体装置を使用しました.
  • 活発に成長する細胞と持続する細胞の間の観察されたフェノタイプの切り替え.
  • 持続性の動態を分析するために定量的な測定を行いました.

主要な成果:

  • Escherichia coliの持続性は,固有の集団の異質性に関連していました.
  • フェノタイプスイッチングは,成長率が低下した持続細胞を生成するメカニズムとして特定されました.
  • 持続性細胞スイッチを記述するために数学的モデルが開発されました.

結論:

  • 固有の細菌の異質性は,環境変動への適応において重要な役割を果たします.
  • 発見は,困難な条件下で細菌の生存戦略の洞察を提供します.
  • 持続性細胞ダイナミクスを理解することは,持続性細菌感染症に対する新しい戦略の開発に不可欠です.