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T細胞受容体/CD3複合体は,少なくとも2つの自律的な変換モジュールで構成されています
A M Wegener1, F Letourneur, A Hoeveler
1Centre d'Immunologie, INSERM-CNRS de Marseille-Luminy, France.
Cell
|January 10, 1992
まとめ
T細胞受容体 (TCR) 複合体は,シグナル伝達のためにCD3サブユニットを使用します. ゼータ鎖がない場合でも,CD3-ガンマ-, -デルタ-, -エプシロンはインタールイキン-2の産生を誘発し,並列の信号伝達経路を示唆する.
科学分野:
- 免疫学 免疫学とは
- 分子生物学は分子生物学である.
- 細胞シグナル伝達 細胞信号伝達
背景:
- T細胞受容体 (TCR) 複合体は,適応性免疫にとって極めて重要です.
- CD3-zetaはTCR信号伝導に関与することが知られている.
- 他の不変のCD3サブユニット (ガンマ,デルタ,エプシロン) の役割は不明である.
研究 の 目的:
- TCRシグナル伝達におけるCD3-ガンマ-, -デルタ-, -エプシロンサブユニットの機能を調査する.
- 機能的なゼータサブユニットがないTCR/CD3複合体が,それでも信号を発信できるかどうかを判断する.
主な方法:
- 機能的なゼータサブユニットがないTCR/CD3複合体の構築.
- 抗原または超抗原刺激に反応するインタールユーキン-2生成の分析.
主要な成果:
- 機能的なゼータサブユニットを持たないTCR/CD3複合体は,インタールイキン-2の産生を誘発する能力を保持した.
- これは,CD3-ガンマ-, -デルタ-, -エプシロン鎖が信号伝導を独立して媒介できることを示している.
- 断片化されたゼータ鎖の分析により,信号伝導に潜在的に関与する機能領域が特定されました.
結論:
- TCR/CD3複合体は,少なくとも2つの並列信号ユニットを構成している可能性が高い:一つはガンマ,デルタ,エプシロン鎖,もう一つはゼータ鎖を含む.
- ゼータ鎖内の保存された機能ドメインは,抗原とFc受容体のシグナルサブユニットの共通の構成要素である可能性があります.
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