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系統性硬化症における欠陥性血管新生
Masataka Kuwana1, Yuka Okazaki, Hidekata Yasuoka
1Institute for Advanced Medical Research Keio University School of Medicine, Tokyo, Japan. kuwanam@sc.itc.keio.ac.jp
Lancet (London, England)
|August 18, 2004
まとめ
系統性硬化症の患者は,循環する内皮前駆体が少なく,血管の修復を損なう. これは,欠陥血管新生が彼らの血管疾患に寄与し,潜在的な治療目標を提供することを示唆しています.
科学分野:
- 心血管生物学 心血管生物学
- 免疫学 免疫学とは
- 再生医学は,再生医療である.
背景:
- システミック硬化症 (SSc) は,毛細血管の密度低下と血管の消去を含む血管損傷によって特徴付けられます.
- 血管新生,つまり血管の形成と修復は,循環する内皮前体 (CEP) に依存しています.
- 血管新生障害は,SSc.で観察された血管病理の根底にある可能性があります.
研究 の 目的:
- 血管新生が全身性硬化症の患者で障害があるかどうかを調査する.
- SSc患者における循環内皮前駆体 (CEP) を,対照群と比較して定量化するために.
- SSc.におけるCEPの差別化可能性を評価する.
主な方法:
- 定量化されたCEP (CD34+,CD133+,VEGFR2+) は,SSc,リウマチ性関節炎,およびフローサイトメトリを用いた健康な対照群の周辺血液で測定された.
- ELISAによる循環性血管新生因子の測定.
- 評価されたCEPの差異化能力は,in-vitro成熟とフォン・ウィレブランド因子発現による.
主要な成果:
- SSc患者は,関節リウマチ患者および健康な対照群と比較して,CEPの絶対値が著しく低いことを示した (p<0.0001).
- 逆説的に,循環する血管新生因子の濃度は,SSc患者で上昇しました.
- 内皮細胞に微分化できるCEPの割合は,SSc患者で有意に減少した (p<0.0001).
結論:
- CEPの減少した数と差異化障害によって示される欠陥血管新生は,全身性硬化症で見られる血管病に寄与する可能性が高い.
- 調節不良の血管新生は,がんや動脈硬化を含む他の血管疾患に関与する可能性があります.
- CEPは,SScにおける不全性合併症の管理のための潜在的な治療目標です.
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