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筋肉繊維のパターンは,産後ネズミの発達における細胞系統とは独立している
1Department of Pharmacology, Stanford University School of Medicine, California 94305-5332.
Cell
|February 21, 1992
まとめ
筋肉繊維のパターンは,発達中のミオブラストの系統によって決定されません. 代わりに,外部の信号が筋肉繊維の発達を誘導し,ミオブラストの固有の遺伝的プログラミングを覆す.
科学分野:
- 発達生物学 発達生物学とは
- 細胞生物学 細胞生物学
- 筋肉の生理学について
背景:
- 筋肉の繊維は,発達する肢体において,明確な速くて遅い収縮パターンを表します.
- 実験室内研究では,特定のミオブラストの系統が,筋肉繊維の種類とパターンを決定する可能性があることが示唆されています.
研究 の 目的:
- 異なるミオブラスト系統が,筋肉繊維のパターンを in vivo で確立する責任があるかどうかを調査する.
- 外的な信号がミオブラストの運命と筋肉繊維のパターンを影響するかどうかを判断する.
主な方法:
- リトロウイルスのラベリングを使用して,個別のミオブラストのクローンを遺伝子的にタグ付けし,追跡しました.
- 発達中の肢体内の異なる筋肉繊維タイプへのラベル付きミオブラストクローンの貢献を分析しました.
主要な成果:
- ミオブラストのクローンは, in situ とか in vitro 培養と移植の後にラベル付けされても,遭遇したすべての筋肉繊維タイプに子孫を寄与しました.
- ミオブラストの子孫は,その起源に基づいて特定の繊維タイプを形成することに制限されないことを実証しました.
結論:
- 産後発達における筋肉繊維のパターンは,ミオブラストの系統によって決定されるものではありません.
- 外的な環境信号は,内的なミオブラストのプログラミングを覆し,筋肉繊維の種類とパターンを決定する上で重要な役割を果たします.
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