アデノシンは,ペースによって引き起こされる心不全においてブラジカルディアを引き起こす
F L Belloni1, J Wang, T H Hintze
1Department of Physiology, New York Medical College, Valhalla 10595.
Circulation
|March 1, 1992
まとめ
心不全では,身体は静脈のトーンを失い,心臓のペースを遅らせるアデノシンの直接的な効果 (ブラジカルディア) を明らかにします. この研究は,アデノシンが心不全に及ぼす負のクロノトロプ的影響を実証しています.
科学分野:
- 心血管生理学 心血管の生理学
- 心臓電気生理学 心臓電気生理学
背景:
- アデノシンは通常,犬の低血圧と反射性心拍の原因となります.
- 陰道切開または閉塞は,シノアトリアルノード阻害経由でアデノシンの直接的なブラディカルジック効果を明らかにします.
研究 の 目的:
- 閉塞性心不全の犬のモデルでアデノシンが心拍数に及ぼす影響を調査する.
- 心不全で管のトーンが失われると,アデノシンの直接的な負のクロノトロピー効果が明らかにされるという仮説を検証する.
主な方法:
- モングレル犬は,血液動力学的モニタリングと心室ペースの計測のための計器を施しました.
- 4週間の心室ペース調節療法は,心不全を誘発した.
- アデノシンは,心不全の発生前と発生中に注射されました.
主要な成果:
- アデノシン誘発の心拍数上昇は,心不全が進行するにつれて減少した.
- 進行した心不全では,アデノシン注射により,心拍数が著しく低下 (ブラジカルディア) した.
- これらのブラディカルディック効果は,同時に抑うつ剤反応があったにもかかわらず発生しました.
結論:
- 心不全における管の失調は,アデノシンによる直接的な負のクロノトロピック効果を明らかにする.
- 外因性アデノシンは,衰弱した心臓のシノアトリアルノード機能を直接抑制する.
関連する概念動画
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