慢性心不全におけるプラズマエンドセリン
J J McMurray1, S G Ray, I Abdullah
1Department of Cardiology, Western Infirmary, Glasgow, UK.
Circulation
|April 1, 1992
まとめ
慢性心不全 (CHF) の患者は,強力な血管圧縮性ペプチドである循環中のエンドセリンのレベルが上昇しています. CHFにおけるこれらのエンドセリン濃度の上昇は,疾患の病理生理学において重要な役割を果たす可能性があります.
科学分野:
- 心血管生理学 心血管の生理学
- エンドクリノロジー エンドクリノロジー
- 神経ペプチド研究 神経ペプチドの研究
背景:
- エンドセリン (endothelins) は,血管圧縮性特性で知られている,新たに発見されたペプチドです.
- 慢性心不全 (CHF) は,外周動脈と腎臓の血管収縮と関連しています.
研究 の 目的:
- 慢性心不全 (CHF) と診断された患者におけるプラズマのエンドセリンのような免疫反応性のレベルを調査する.
主な方法:
- 重度のCHFの患者および健康なボランティアの周周周静脈プラズマエンドセリン濃度の測定.
- 運動中のエンドセリン濃度の評価.
- 血の心房ナトリウレティック因子,血清尿素,血清クレアチニンとの相関分析.
- 腎臓エンドセリン抽出の評価.
主要な成果:
- 重度のCHFの患者は,健康な対照群 (6.4 +/- 0.3 pmol/l) と比較して,プラズマエンドセリン濃度 (12.4 +/- 0.6 pmol/l) が著しく高かった.
- 血のエンドセリンの濃度は,両方のグループで運動によって変化しませんでした.
- プラズマエンドセリンと心房ナトリウレティック因子,尿素,またはクレアチニンの間の有意な相関は,CHFの患者では見つかりませんでした.
- CHFの患者では,エンドセリンの重要な腎臓抽出が観察されました.
結論:
- 5~40 pmol/lの範囲内の循環中のエンドセリンの濃度は,血管活性であることが示唆されています.
- CHFの患者で検出されたエンドセリン濃度の上昇は,この症候群の病理生理学的な意味を持つ可能性が高い.
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