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アスピリンによって誘発され,サイクロオキシゲネーゼ2に依存するリポキシンの合成は,血管トーンを調節する
Pierre-Yves von der Weid1, Morley D Hollenberg, Stefano Fiorucci
1Mucosal Inflammation Research Group, University of Calgary, Calgary, Alberta, Canada.
Circulation
|August 25, 2004
まとめ
アスピリンによって誘発されるリポキシンA (A) は,血管のトーンと血圧に影響を与えます. リポキシン合成の阻害はアスピリンの圧縮効果を強め,心血管の調節におけるリポキシンの役割を強調する.
科学分野:
- 心血管生理学 心血管の生理学
- 炎症生物学 炎症生物学とは
- 薬理学 薬理学とは
背景:
- アスピリンは,抗炎症性および胃を保護する作用で知られている15-R-エピリポキシンA (ATL) の生成を誘発します.
- 血管トーンに対するATLの影響とアスピリンの心血管効果におけるその役割は,ほとんど未知のままである.
研究 の 目的:
- アスピリンによって誘発された血管トーンの変化に対するATLの貢献を調査する.
- アスピリンとATLの血管効果を媒介する窒素酸化物 (NO) の役割を調べる.
主な方法:
- アスピリンの投与後の血圧 (BP) の評価変化 in vivo.
- ATL合成を調節するために選択性サイクロオキシゲネーゼ-2および5-リポキシゲネーゼ阻害剤,リポキシン受容体アンタゴニスト (Boc2) および中性粒子の免疫低下を利用した.
- リポキシンAの血管リラックス作用が確認された (ライポキシンAの血管リラックス作用が確認された) 単離されたラット大動脈と中枢動脈のセグメントで,内皮依存性を評価した.
主要な成果:
- 静脈内リポキシンA (((4) は,血圧の一時的な低下を引き起こしました.
- アスピリンは血清ATLとBPを増加させ,ATL合成を阻害すると,アスピリンが誘発したBPの増加が著しく増加した.
- リポキシンA ((4) は,隔離された動脈におけるエンドセリウム依存の血管リラックスを引き起こした.
結論:
- アスピリンによって誘発されるリポキシンの合成は,血管トーンと全身血圧を調節する.
- リポキシンは,炎症反応の際に地域の血流を調節する役割を果たす可能性があります.
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