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Updated: Jul 14, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
09:49

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Published on: July 5, 2019

Eタンパク質は,白血病原性AML1-ETO融合タンパク質によって静音化されます

Jinsong Zhang1, Markus Kalkum, Soichiro Yamamura

  • 1Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Science (New York, N.Y.)
|August 31, 2004
PubMed
まとめ

急性骨髄性白血病 (AML) のAML1-ETO融合タンパク質は,コアクティベーター結合を防ぐことでEタンパク質の機能をブロックする. この相互作用は正常な遺伝子調節を妨害し,白血病の発症に寄与する.

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