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Updated: Jul 6, 2026

Assays for the Degradation of Misfolded Proteins in Cells
10:56

Assays for the Degradation of Misfolded Proteins in Cells

Published on: August 28, 2016

チャペロン媒介の自性による変異性アルファシヌクレインの劣化障害

Ana Maria Cuervo1, Leonidas Stefanis, Ross Fredenburg

  • 1Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. amcuervo@aecom.yu.edu

Science (New York, N.Y.)
|August 31, 2004
PubMed
まとめ

ワイルドタイプのアルファ・シヌクレインは,チャペロン媒介のオートファギーを介して分解される. 病原性ミュータントは,この経路をブロックし,潜在的にパーキンソン病の毒性を引き起こします.

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