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Updated: Jul 6, 2026

Interview: Protein Folding and Studies of Neurodegenerative Diseases
19:50

Interview: Protein Folding and Studies of Neurodegenerative Diseases

Published on: July 16, 2008

リボソームと複合したトリガーファクタは,新生タンパク質の分子のゆりかごを形成します

Lars Ferbitz1, Timm Maier, Holger Patzelt

  • 1Institut für Molekularbiologie und Biophysik, Eidgenössische Technische Hochschule Hönggerberg (ETH Zürich), HPK Gebäude, CH-8093 Zürich, Switzerland.

Nature
|August 31, 2004
PubMed
まとめ

タンパク質の折りたたみを支援するチャペロンであるEscherichia coliトリガーファクターには,ユニークな"クルーチングドラゴン"構造があります. この構造は,リボソームから発生する新生ポリペプチドを遮断し,共翻訳折り合いの際に結合とプロテアゼの分解を防止します.

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