早期冠動脈疾患の患者における家族性リポプロテイン疾患
J J Genest1, S S Martin-Munley, J R McNamara
1Lipid Metabolism Laboratory, U.S.D.A. Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.
Circulation
|June 11, 1992
まとめ
遺伝性リポプロテイン障害は,早発性冠動脈疾患 (CAD) で一般的です. 早期CADの患者の半数以上は,過剰なリポプロテイン (a) と低いHDLコレステロールを含む家族性脂質障害を持っています.
科学分野:
- 心血管遺伝学 心血管遺伝学
- 脂質代謝についてです.
- 動脈硬化症の研究研究
背景:
- 遺伝性リポプロテイン疾患は,早発性冠動脈疾患 (CAD) と関連しています.
- 家族性脂質異常を理解することは,CADのリスク評価に不可欠です.
研究 の 目的:
- 早期CADの個体における遺伝性リポプロテイン疾患の有病率を決定する.
- 早期発症のCADに関連した特定の家族性脂質異常を特定するために.
主な方法:
- 102人の親族 (603人の被験者) の早期CADの脂質プロファイル (コレステロール,トリグリセリド,LDL,HDL,apo B,apo A-I,Lp(a)) を分析した.
- 年齢および性別特有の基準 (90パーセント以上または10パーセント以下) に基づく異常な脂質レベルを定義します.
- 早期CADのプロンバードにおける脂質異常を,年齢相応の対照群と比較した.
主要な成果:
- 73.5%の早発性CADの試験参加者は,異常な脂質レベルを示し,対照群の38.2%と比較した.
- ハイポアルファリポプロテイン血症 (低HDLコレステロール) は,最も頻度の高い異常 (39.2%) であった.
- 定義された家族性リポプロテイン障害は,親族の54%で特定され,過剰なLp(a),ハイパートリグリセリデミアとハイポアルファリポプロテイン血症,ハイパーリピデミアとハイポアルファリポプロテイン血症の組み合わせが最も一般的でした.
結論:
- 家族性リポプロテイン疾患は,早発性CADの患者の半数以上に存在します.
- 過剰なLp (a) とハイポアルファリポプロテイン血症のような特定の脂質異常は,重大なリスク要因です.
- 遺伝的要因は,脂質タンパク質のレベルを決定する上で重要な役割を果たし,CADリスクに影響を与えます.
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