慢性的なコカイン中毒者におけるトレッドミルの運動に対する過剰なプレッサー反応,左心房縮症
C G Cigarroa1, J D Boehrer, M E Brickner
1Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas 75216.
Circulation
|July 1, 1992
まとめ
慢性的なコカイン乱用は,左心室縮症 (LVH) と関連しています. LVHを持つコカイン乱用者は,運動中に過剰な血圧上昇を示し,LVHの発症に役割を果たしていることを示唆しています.
科学分野:
- 心臓病学 心臓病学
- 運動生理学 運動生理学
- 薬物乱用研究 薬物乱用研究
背景:
- 慢性的なコカイン乱用は,正常な静止血圧を有する個体において,左心房高縮症 (LVH) と頻繁に関連しています.
- コカイン誘発のLVHと運動に対する心血管の反応の関係はまだ不明です.
研究 の 目的:
- 慢性的にコカインを乱用し,LVHを患っている人は,トレッドミルの運動中に過剰なプレッサー反応を示すかどうかを調査する.
- コカイン使用者のLVHの病原性に対する運動による高血圧の潜在的貢献を調査する.
主な方法:
- 49人のノルモテンシブな慢性的なコカイン中毒者および年齢/人種を合わせた対照群が,ブルースプロトコルトレッドミル運動テストを受けた.
- 2次元エコーカルディオグラフィーは,LVH診断のための左心室質量と後部壁の厚さを決定するために使用されました.
- ピークエクササイズシストリック血圧が記録され,異常は≥210mmHgとして定義されました.
主要な成果:
- コカイン乱用者の33%に左心房縮 (LVH) が存在し,対照群では10%であった (p=0.02).
- LVHを持つコカイン乱用者は,LVHと対照群の患者と比較して,ピークエクササイズシストリック血圧が有意に高かった (p=0.0001).
- LVHを患ったコカイン乱用者の63%は,異常なピーク運動シストリック血圧 (≥210 mm Hg) を有していた.
結論:
- LVHの慢性的なコカイン中毒者は,トレッドミルの運動に対する過剰なプレッサー反応を示します.
- 運動のような共感的な刺激に対するこの高い反応は,敏感な個体において,LVHの発生に寄与する可能性がある.
- 研究結果は,コカインの乱用が,運動誘発性高血圧およびLVHを含む,心血管の変化に個人を易感させる可能性があることを示唆しています.
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