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Updated: Jul 15, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

イミノ酸とコラーゲンのトリプルヘリックス安定性:Hyp-Hyp-Gly配列の繰り返しを含むコラーゲンのようなポリペプチドの特徴

Rita Berisio1, Vincenzo Granata, Luigi Vitagliano

  • 1Istituto di Biostrutture e Bioimmagini, CNR; Dipartimento di Chimica Biologica, Università degli Studi di Napoli Federico II, Centro interuniversitario di ricerca sui Peptidi bioattivi (C.I.R.P.E.B.), Via Mezzocannone 6, I-80134 Naples, Italy.

Journal of the American Chemical Society
|September 16, 2004
PubMed
まとめ

コラーゲンのようなポリペプチドのX位置にあるヒドロキシプロリン (Hyp) は,トリプルヘリックスを著しく安定させます. 分子モデリングは,この安定化は,隣接する鎖のHyp残基間の水素結合によるものであることを明らかにしています.

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