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Updated: Jul 16, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

水核塩基"積み重ね":RNAの擬似結び目の原子解像度の結晶構造におけるH-piと単一のペア-piの相互作用

Sanjay Sarkhel1, Alexander Rich, Martin Egli

  • 1Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA.

Journal of the American Chemical Society
|September 17, 2004
PubMed
まとめ

アロマティックリングは,水素-pi (H-pi) と単一対-pi (l.p.-pi) の相互作用を通じて,RNA構造の水分分子と相互作用する. この研究は,結晶構造におけるl.p.-pi相互作用の存在を確認し,理論的予測と一致しています.

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Practical Aspects of Sample Preparation and Setup of 1H R1ρ Relaxation Dispersion Experiments of RNA

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Visualization and Quantification of Intermolecular RNA Base Pairing in in vitro RNA Clusters Using Split Broccoli RNA Reporters10:52

Visualization and Quantification of Intermolecular RNA Base Pairing in in vitro RNA Clusters Using Split Broccoli RNA Reporters

Published on: May 29, 2026

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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¹H NMR: Complex Splitting

A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied first.
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Interpreting ¹H NMR Signal Splitting: The (n + 1) Rule

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¹H NMR: Pople Notation

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Nucleic Acid Structure

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