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高用量アスピリンは,トロンビン生成を伴う切断誘発性血小板反応を抑制する

C P Ratnatunga1, S F Edmondson, G M Rees

  • 1Department of Cardiothroracic Surgery, St. Bartholomew's Hospital Medical School, London.

Circulation
|March 1, 1992
PubMed
まとめ

アスピリンの75mg/日投与は,手術後の血小板過剰反応を完全に防ぐことはできませんでした. 切断誘発性血小板反応を抑制するために,より高いアスピリン用量 (300 mg/日以上) が必要であり,これは,血栓糖抑制を超えたメカニズムを示唆する.

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