開胸犬における除細動の値と脆弱性の上限との関係に対するリドカインの効果
S L Topham1, Y M Cha, B B Peters
1Department of Medicine, University of California San Diego Medical Center 92103-8411.
Circulation
|March 1, 1992
まとめ
リドカインは,犬の défibrillation 値 (DFT50) と脆弱性の上限 (ULV50) を上昇させます. しかし,ULV50はDFT50よりも多く上昇し,他の要因が除細動に影響することを示唆しています.
科学分野:
- 心血管生理学 心血管の生理学
- 薬理学 薬理学とは
背景:
- デフィブリレーションの値と脆弱性の上限との関係は,デフィブリレーションの有効性を理解するために重要である.
- リドカイン (lidocaine) は,心電生理学に既知の効果を有する抗不律薬である.
研究 の 目的:
- リドカインが除細動の値 (DFT50) と脆弱性の上限 (ULV50) に与える影響を調査する.
主な方法:
- オープンチェスト犬は,リドカイン注入前およびその間,DFT50およびULV50を決定するために使用されました.
- 遅延アップダウン法とパッチパッチの電極構成が採用されました.
- 血清リドカイン濃度および心電図パラメータ (QT間隔,QRS複合体) をモニターした.
主要な成果:
- リドカインは犬のULV50とDFT50の両方を有意に増加させた.
- ULV50は,リドカイン注入中にDFT50よりも大きな増加を示しました.
- 通常の塩水注入はULV50やDFT50.0に影響を与えませんでした.
結論:
- リドカインの投与は,脆弱性の上限と除細動の値の両方を上昇させます.
- 発見は,除細動の脆弱性仮説の上限を支持する.
- ULV50の不釣り合いの増加は,リドカイン治療中に除細動の結果に影響を与える追加の要因を示唆しています.
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