炎症への曝露と人間の寿命における過去の変化
Caleb E Finch1, Eileen M Crimmins
1Andrus Gerontology Center and Departments of Biological Sciencesand of Sociology, University of Southern California, Los Angeles, CA 90089, USA. cefinch@usc.edu
Science (New York, N.Y.)
|September 18, 2004
まとめ
コホートメカニズムである伝染病や炎症への曝露を生涯にわたって減らすことにより,高齢死亡率が著しく低下しています. 早期の死亡率は,後の人生の結果を強く予測し,持続的な"コホート発病現象型"を示唆しています.
科学分野:
- デモグラフィー デモグラフィー 人口統計
- エピデミオロジー エピデミオロジー
- 公衆衛生は公衆衛生である.
背景:
- 平均寿命の歴史的増加は,しばしば医学と公衆衛生の進歩に起因する.
- 生涯にわたる炎症性曝露の減少を含むコホートベースのメカニズムは,完全に調査されていません.
研究 の 目的:
- 伝染病と炎症に対する生涯暴露の減少が,高齢死亡率の歴史的減少における役割を調査する.
- 出生コホートにおける早期死亡率と後の死亡率の関連性を調べる.
主な方法:
- 1751年以降のスウェーデンの出生コホートの分析.
- 特定の出生コホートにおける生涯における死亡率パターンの検討.
主要な成果:
- 同じコホートにおける早期死亡率と後の死亡率の間に強い関連性が見られた.
- これは,生命の初期に発生した"コホート発症現象型"と呼ばれる持続的な炎症過程を示唆しています.
結論:
- コホート効果である炎症への生涯暴露の減少は,高齢死亡率の減少に大きく貢献しています.
- "コホート病変性現象型"は,生命の初期における炎症プロセスが,生命の後の健康結果に及ぼす長期的な影響を強調しています.
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