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Updated: Jul 10, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
09:42

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

陽性電荷の活性サイト群との静電相互作用は,酵素性酸化塩基移転の移行状態を厳しくするのでしょうか?

Ivana Nikolic-Hughes1, Douglas C Rees, Daniel Herschlag

  • 1Department of Chemical Engineering, Stanford University, Stanford, California 94305, USA.

Journal of the American Chemical Society
|September 24, 2004
PubMed
まとめ

アルカリリンフォスファターゼ (AP) 触媒は,アリル硫酸塩とフォスフォロチオ酸塩の水解に類似した移行状態を示し,活性部位における最小限の静電効果を示しています. この発見は,酵素反応のメカニズムを明確にします.

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