塩酸塩酸を服用している患者の甲状腺機能検査の結果の異常
1Columbia University College of Physicians and Surgeons, New York, NY.
JAMA
|March 4, 1992
まとめ
サルサラテは甲状腺機能検査を著しく変えて,チロキシン (T4) と自由T4指数値を低下させ,中央性甲状腺機能低下症を模倣する. しかし,これらの薬剤による変化にもかかわらず,患者は臨床的にユータイロイド状態のままです.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 薬理学 薬理学とは
背景:
- 甲状腺機能検査は,甲状腺障害の診断に不可欠です.
- 非ステロイド性抗炎症薬 (NSAIDs) は,潜在的に甲状腺ホルモンレベルに干渉する可能性があります.
研究 の 目的:
- 標準的な甲状腺機能検査結果に対する塩塩酸の影響を調査する.
- 塩酸塩酸が甲状腺機能低下症を示す生化学的変化を引き起こすかどうかを判断する.
主な方法:
- 統合失調症の患者14人のコホートを研究した.
- 甲状腺機能検査は,塩塩酸治療を受けた患者と,それを受けなかった患者に実施した.
- 血清中のT4,自由T4,T3およびチロトロピンの濃度が測定されました.
主要な成果:
- サルサラテは,血清T4および自由T4指数値を有意に低下させ,甲状腺機能低下の範囲に入っていた.
- また,フリーT4とトライヨドチロニンの総濃度は,塩酸塩酸を摂取した一部の患者で低かったことが判明しました.
- タイロトロピンの濃度は,3週間未満に治療された患者で一時的な減少を示した.
結論:
- サルサラートはしばしば,中枢性甲状腺機能低下症に似た異常な甲状腺機能検査結果を引き起こす.
- 生物化学的変化にもかかわらず,塩酸塩で治療された患者は臨床的に無甲状腺状態を保った.
関連する概念動画
01:15Myasthenia Gravis: Diagnostic Tests
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
01:27Adrenal Gland Disorders
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
01:24Diagnosing Acidosis and Alkalosis
Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and HCO3− values are examined to...
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and HCO3− values are examined to...
01:25Assessment of the Rectum and Anus
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
01:30Serum Laboratory Studies, Stool Test, Breath Test
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...