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神経末端におけるPtdIns ((4,5) P2合成の障害は,シナプス膀のトラフィックの欠陥を生成する

Gilbert Di Paolo1, Howard S Moskowitz, Keith Gipson

  • 1Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

Nature
|September 24, 2004
PubMed
まとめ

フォスファディチルイノシトール-4,5-ビスホスファート (PtdIns(4,5) P2) は,シナプス胞の循環に不可欠です. マウスにおけるその合成の障害は,重度のシナプス欠陥と早期死亡を引き起こし,神経末端機能における重要な役割を強調する.

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