血液の脂質の測定. 血液の脂質の測定. 血液の脂質の測定. 血液の脂質の測定. バリエーションと実用的なユーティリティ
G R Cooper1, G L Myers, S J Smith
1Division of Environmental Health Laboratory Sciences, Centers for Disease Control, Atlanta, GA 30333.
JAMA
|March 25, 1992
まとめ
生物学的および分析学的変動は,血清脂質レベルと冠動脈疾患のリスクに大きな影響を与えます. これらの変化を理解することは,患者の真のコレステロールを推定し,検査頻度をガイドするのに役立ちます.
科学分野:
- 臨床化学 臨床化学について
- 心血管疾患のリスク評価
- バイオ統計学 バイオ統計学
背景:
- 血清脂質と脂質タンパク質レベルは,冠動脈疾患 (CHD) リスクの重要な指標です.
- 重要な生物学的および分析的変動は,これらの測定の精度に影響を与える可能性があります.
- 脂質検査結果を解釈するには,変動の源と大きさを理解する必要があります.
研究 の 目的:
- 血清脂質および脂質タンパク質濃度の変動の主要な生物学的および分析的原因を定量化する.
- CHDリスクに対するこれらの変動の影響を評価する.
- 個体内での変動を推定し,正確なコレステロール評価のために必要な標本数を決定するための方法を提供する.
主な方法:
- 脂質変動源に関する300以上の出版物の体系的レビュー.
- 標準化された条件,明確な結果,許容可能な実験設計に基づく研究の選択.
- 代表的な脂質レベルのための標準化ラボからの定量的な測定を用いた.
主要な成果:
- 分析前の変動 (行動的,臨床的,サンプリング) は,脂質測定の総変動の約60%を占めています.
- 2〜3つの連続標本を使用して個体内生物学的変化を推定するための定性的な方法が提示されています.
- 統計分析はデータの信頼性を確認したが,推定方法は定性的な結果をもたらした.
結論:
- 分析前の要因は,個々の脂質測定における変動の主要な源である.
- 医師は,患者特有の変動を推定し,国家コレステロール教育プログラム (NCEP) のガイドライン (個体内変動係数<5.0%) の遵守を確保するために,提示されたテクニックを使用することができます.
- 全国リファレンスメソッドネットワークは,脂質検査における分析的な課題に対処することを目的としています.
関連する概念動画
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