母親のカルシウム摂取量と子育ての血圧
Matthew W Gillman1, Sheryl L Rifas-Shiman, Ken P Kleinman
1Department of Ambulatory Care and Prevention, Harvard Medical School/Harvard Pilgrim Health Care, Boston, Mass 02215, USA. matthew_gillman@hms.harvard.edu.
Circulation
|September 29, 2004
まとめ
妊娠中の母親によるカルシウム補給は,子孫の血圧を低下させる可能性があります. この発見は,胎児の栄養による将来の高血圧の予防のための潜在的な戦略を示唆しています.
科学分野:
- 産婦人科と産婦人科を担当しています.
- 小児科は小児科です.
- 栄養科学とは,栄養科学である.
背景:
- 妊娠中の母親のカルシウム摂取が子孫の血圧にどのように影響するかに関するデータは限られている.
- この世代間のつながりを理解することは,長期的な心血管の健康にとって極めて重要です.
- Project Vivaは,米国の進行中の前向きなコホート研究で,子どもの健康に影響を与える要因を調査しています.
研究 の 目的:
- 妊娠中の母親のカルシウム摂取量と6ヶ月の子供の血圧の関連性を調査する.
- 栄養カルシウムまたはサプリメントカルシウムの摂取が乳児の血圧に差異的な影響を与えているかどうかを判断する.
- 母親のビタミンDとカリウム摂取量などの,この関係の潜在的な変形因子を調査する.
主な方法:
- Project Vivaコホートにおける936人の乳児からの4091人の血圧測定値の分析.
- 妊婦の食事およびサプリメントによるカルシウム摂取量は,妊娠2期間の食事頻度に関するアンケートで評価された.
- 混合モデルを使用して,母親のカルシウム摂取が乳児の静脈動脈血圧に及ぼす影響を推定し,様々な共変数に対する調整を行った.
主要な成果:
- 平均的な母親の1日のカルシウム摂取量は1494mg (1230mgは食物から,264mgはサプリメントから) でした.
- 乳児の静脈動脈血圧の有意な傾向は,食物から摂取する食中のカルシウム摂取量 (P=0.62) を増加させると観察されなかった.
- 乳児の収縮血圧の有意な低下 (500 mg増量あたり3.0 mm Hg) は,完全調整後の母親の補足カルシウム摂取量 (P=0.006) と関連していました.
結論:
- 妊娠中期の母親のサプリメントカルシウム摂取は,6ヶ月後の子孫の低血圧と関連している可能性があります.
- これらの発見は,カルシウム補給が次世代における高血圧の予防に役立つ戦略である可能性があることを示唆しています.
- 最初の3ヶ月間のカルシウム摂取量は,子孫の血圧と関連を示さなかった.
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