カナビノイド-1受容体に作用するエンドカンナビノイドは,高血圧の心血管機能を調節します
Sándor Bátkai1, Pál Pacher, Douglas Osei-Hyiaman
1Laboratory of Physiologic Studies, National Institute on Alcohol Abuse & Alcoholism, National Institutes of Health, Bethesda, Md 20892-8115, USA.
Circulation
|September 29, 2004
まとめ
アナンドマイドのようなエンドカンナビノイドは,高血圧の血圧を調節するのに役立ちます. 降解を阻害することによってその効果を高めると,高血圧のネズミの血圧と心臓の機能を正常化する.
科学分野:
- 心血管生理学 心血管の生理学
- エンドクリノロジー エンドクリノロジー
- 薬理学 薬理学とは
背景:
- エンドカンナビノイドは,既知の低血圧および心圧縮効果を有する脂質媒介体です.
- 心血管の調節,特に高血圧におけるエンドカンナビノイドシステムの役割については,さらなる調査が必要である.
研究 の 目的:
- 高血圧における心血管機能の調節におけるエンドカンナビノイドシステムの役割を調査する.
- エンドカンナビノイド活性を調節することで,高血圧モデルにおける血圧と心臓の機能に影響があるかどうかを判断する.
主な方法:
- 研究は,自発的に高血圧のラット (SHR) と正常血圧のWistar-Kyotoラットで行われました.
- 治療には,カンナビノイド-1受容体 (CB1) アナゴニスト,アナンダミドの分解を防ぐための脂肪酸アミドヒドローラゼ (FAAH) 阻害剤,CB1アゴニストが含まれていました.
- 測定には,血圧,左心房の収縮性能,および血管抵抗が含まれていました.
主要な成果:
- CB1アンタゴニストは,SHRにおける血圧と心臓の収縮性を増加させた.
- アナンドマイドの分解を阻害することで,SHRにおける血圧,心臓の収縮性,および血管抵抗をノルモテンシブレベルまで低下させました.
- これらの効果は,CB1アンタゴニストによって阻害され,ノルモテンシブラットでは観察されなかった.
- CB1アゴニストは,ノルモテンシブラットと比較して,SHRでより大きな低血圧効果を示した.
- CB1受容体発現は,SHRの心臓と大動脈内皮に上昇した.
結論:
- エンドカンナビノイドは,高血圧状態における心臓の収縮性に対するトニック抑制効果を発揮する.
- 水解抑制による内生アナンダミドのCB1媒介作用の強化は,血圧を正常化させることができます.
- エンドカンナビノイド系は,高血圧管理の有望な治療目標です.
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