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Updated: Jul 11, 2026

Changing the Direction and Orientation of Electric Field During Electric Pulses Application Improves Plasmid Gene Transfer in vitro
04:46

Changing the Direction and Orientation of Electric Field During Electric Pulses Application Improves Plasmid Gene Transfer in vitro

Published on: September 12, 2011

遺伝子配送のための電荷逆転アンフィフィール

Carla A H Prata1, Yuxing Zhao, Philippe Barthelemy

  • 1Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA.

Journal of the American Chemical Society
|September 30, 2004
PubMed
まとめ

研究者らは,電荷逆転アンフィファイルの利用で新しい遺伝子配送ベクトルを開発した. この合成ベクトルは,既存のカチオンベクトルと比較して,遺伝子トランスフェクションの効率を向上させます.

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Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
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Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...