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Updated: Jul 11, 2026

Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System
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Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System

Published on: March 18, 2010

インタースティシャル・コラーゲナーゼは,コラーゲンのタンパク質分解によって駆動されるブラウン式ラチェットです

Saveez Saffarian1, Ivan E Collier, Barry L Marmer

  • 1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.

Science (New York, N.Y.)
|October 2, 2004
PubMed
まとめ

活性化されたコラーゲナーゼ (MMP-1) は,ATPではなく,基質のタンパク質分解によって引き起こされる,コラーゲンに対するバイアス的な拡散を示します. この分子ラチェットメカニズムは,組織再構築と細胞-マトリックス相互作用において極めて重要です.

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