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Updated: Aug 1, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
11:36

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones

Published on: July 25, 2019

ウビスタチンは,ユビキチン鎖を結合することによって,プロテアソーム依存的な分解を阻害します

Rati Verma1, Noel R Peters, Mariapina D'Onofrio

  • 1Department of Biology, Howard Hughes Medical Institute (HHMI), California Institute of Technology, Pasadena, CA 91125, USA.

Science (New York, N.Y.)
|October 2, 2004
PubMed
まとめ

研究者は,重要なタンパク質のプロテアソームの分解を阻害することによって,細胞サイクル進行を停止する新しい小分子であるウビスタチンを発見しました. これらのウビスタチンは,ユビキチン鎖相互作用を標的とし,ユビキチン-プロテアゾームシステムを破壊します. キーワード:ウビスタチン,細胞サイクル,プロテアソーム,ウビキチン-プロテアソーム系.

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