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Updated: Jul 22, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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ヒトの炭酸アンヒドラゼIIの双方向性阻害剤

Bidhan C Roy1, Abir L Banerjee, Michael Swanson

  • 1Department of Chemistry, Biochemistry & Molecular Biology, North Dakota State University, Fargo, North Dakota 58105, USA.

Journal of the American Chemical Society
|October 14, 2004
PubMed
まとめ

研究者らは,酵素阻害剤の結合親和性を改善するために,新しい"二端"戦略を開発しました. 表面残留物と相互作用するテザー群を加えることで,ヒト炭酸アンヒドラゼIIに対する阻害力が大幅に強化されました.

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