tPA/プラズミンによるproBDNFの割れは,長期の海馬の可塑性にとって不可欠である

Petti T Pang1, Henry K Teng, Eugene Zaitsev

  • 1Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development (NICHD), Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|October 16, 2004
PubMed
まとめ

組織プラズミノゲン活性化剤 (tPA) は,プロ-BDNFを成熟したBDNF (mBDNF) に変換し,長期記憶形成の重要なステップです. このmBDNFは,タンパク質合成が阻害されたときに,長期的な増強を助けます.

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