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Updated: Jul 12, 2026

Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9
08:27

Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

Published on: April 10, 2018

ホモログな再結合は,ヒトのテロメアでTループサイズのデレーションを生成する

Richard C Wang1, Agata Smogorzewska, Titia de Lange

  • 1Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Cell
|October 28, 2004
PubMed
まとめ

変異したTRF2タンパク質 (TRF2DeltaB) はテロメア末端の結合を抑制したが,DNAの欠損を引き起こした. XRCC3に依存するこれらの切除は,テロメアサークルを形成し,同質再結合 (HR) がテロメアの長さと完全性に影響することを示唆しています.

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